Salvianolic acid B binds to Src and ameliorates mesenteric venules hyperpermeability in endotoxmia rats
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چکیده
منابع مشابه
Salvianolic Acid B Ameliorates Lipopolysaccharide-Induced Albumin Leakage from Rat Mesenteric Venules through Src-Regulated Transcelluar Pathway and Paracellular Pathway
Lipopolysaccharide (LPS) causes microvascular barrier disruption, leading to albumin leakage from microvessels resulting in a range of disastrous sequels. Salvianolic acid B (SalB) is a major water-soluble component derived from Salvia miltiorrhiza. Previous studies showed its potential to attenuate microvascular barrier dysfunction, but the underlying mechanism is not fully understood. The pre...
متن کاملSalvianolic Acid B Ameliorates Motor Dysfuntion in Spinal Cord Injury Rats
Purpose: To evaluate the effect of salvianolic acid B (Sal B) treatment on the motor function of spinal cord injury (SCI) rat. Methods: SCI rats were modelled by contusion, and then received 10 mg/kg Sal B, or methylprednisolone, or phosphate-buffered saline (PBS) intraperitoneally daily for 4 weeks, two hours after the trauma occurred. During the treatment, footprint analysis (FA), inclined pl...
متن کاملSalvianolic Acid B Alleviating Myocardium Injury in Ischemia Reperfusion Rats
BACKGROUND Salvia miltiorrhiza (SM) Bunge is one of the widely-used Chinese medicinal herbs. Salvianolic acid B (Sal B), a bioactive compound isolated from the Chinese herb Radix Salviae Miltiorrhizae, has been reported to exhibit anti-inflammatory and anti-oxidantive effects. MATERIAL AND METHOD To study the cardioprotective effects of salvianolic acid B (Sal B) on acute myocardial ischemia ...
متن کاملSalvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice through the AMPK Pathway.
BACKGROUND/AIMS Salvianolic acid B (Sal B), a major polyphenolic compound of Salvia miltiorrhiza Bunge, has been shown to possess potential antidiabetic activities. However, the action mechanism of SalB in type 2 diabetes has not been investigated extensively. The present study was designed to investigate the effects of Sal B on diabetes-related metabolic changes in a spontaneous model of type ...
متن کاملSalvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats
Nephrotic syndrome (NS) is still a therapeutic challenge. To date there is no ideal treatment. Evidence suggest that multidrug therapy has more effect than monotherapy in amelioration of renal injury. Salvianolic acid A (SAA) is the major active component of Salviae Miltiorrhizae Bunge. Previous studies have demonstrated that SAA is a multi-target agent and has various pharmacological activitie...
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ژورنال
عنوان ژورنال: Microvascular Reviews and Communications
سال: 2014
ISSN: 1880-5906,2188-1707
DOI: 10.14532/mvrc.7.36a